Xudong Huang
Xudong Huang, Harvard Medical School, USA
Title: Exposure of CuO nanoparticles-its nanoneurotoxicity and potential link to neurodegeneration
Biography
Biography: Xudong Huang
Abstract
Growing evidence has indicated that exposure of nanoparticles such as MnO2, CuO, TiO2, etc., due to increasing use of these engineered nanomaterials (ENMs), induces nanoneurotoxicity that may pose risks for having neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), etc. However, the mechanisms of in vivo exposure and its potential contribution to neurodegeneration are not well known. Hence, our long-range objective is to study exposure of ENMs such as CuO nanoparticles and their nanoneurotoxicity and potential correlation to human diseases such as AD as Cu is abnormally enriched in Aβ amyloid deposits of AD patients’ brain. In addition, previous observations and our data also suggest that: (i) long-term exposure to severe air pollution (highly possible exposure of metal oxide nanoparticles) is associated with neuroinflammation, BBB disruption, and Aβ amyloid accumulation (the salient neuropathological features of AD); (ii) CuO nanoparticle exposure increases BBB permeability via inhalation; (iii) exposure of CuO nanoparticles induces in vitro neurotoxicity, inflammation, and oxidative stress. In this keynote speech, the speaker will share and discuss his lab’s recent work on exposure of CuO nanoparticles and resulting nanoneurotoxicity, and its potential link to neurodegenerative diseases such as AD.